Similar to the pattern observed in the total population, the POLE -mutated group had a median TMB of 248.12 muts/Mb, significantly higher than that of the pMMR-IHC/MSS-PCR patients (8.13 muts/Mb) ( p = 0.025), however, the differences between the POLE -mutated patients and the two discordant subgroups, the median TMB of which were both 7.14 muts/Mb, did not reach statistical significance, probably due to the small sample sizes (Fig. 4 b).
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A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.
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