Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells.

Interestingly, Pappa itself was slightly but significantly upregulated, and Igf2 showed a trend toward upregulation, suggesting a partial compensatory response.

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PAPP‐A inhibition resulted in a relatively mild, but highly significant, effect on multiple bone parameters in both sexes, both cortical and trabecular, in the femur and the L5 vertebra (Figure 2A , S3A).

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