Male‐specific variants were identified as those that (1) were significantly associated with longevity in males ( p male < 5 × 10 −8 ) but not significant in females ( p female > 0.05), and (2) exhibited a nominally significant sex difference ( p ‐value testing for difference in sex‐specific effect estimates, p difference < 0.05; formula 1 ).
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Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.
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