Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8⁺ T Cell Tolerance Development.

Similarly, at the end of the experimental timeline 60 days after skin transplantation, mice pre-treated with pGal-OVA-incubated hepatocytes still displayed a trend for a lower frequency of H-2Kb/SIINFEKL-specific CD3 + CD8 + splenocytes (0.16%) compared to mice pre-treated with either wt hepatocytes or vehicle (0.25 and 0.27%, respectively), even though differences at this time point did not reach statistical significance ( Figure 6C , right).

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