Barely Significant
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Longitudinal Assessment of Immune Responses to Repeated Annual Influenza Vaccination in a Human Cohort of Adults and Teenagers.

Front Immunol · 2021 · PMC7965973 · PMID 33746985

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However, due to the limited sample size in each subgroup, these estimates did not reach statistical significance at the 0.05 level.

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an increasing trendno p-value reported
Interestingly, we also noticed an increasing trend of such fold changes in most strains among adults vaccinated in 2016–2017.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.