Cellular responses to deproteinized bovine bone mineral biofunctionalized with bone-conditioned medium.

Interestingly, whereas there were no significant differences between the individual effects of BCM and fresh bone chips, there was an additive and in most of the cases extremely significant ( P < 0.001) effect of fresh bone chips combined with BCM-coated DBBM on the osteogenic gene expression at all three time points (dark green bars).

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6 ) genes showed a slightly different pattern of upregulated expression in cells grown on BCM-coated DBBM compared to control cells, with a clear trend of continuous upregulation over 7 days.

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