Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus.

Nevertheless, when the response to nucleosomes was compared between mouse strains, CD69 expression was only significantly enhanced on total splenocytes from DNase1 −/− /Trap1 m / m mice in comparison to both wild type and DNase1 lacZ / lacZ mice ( Figure 6C ), but did not reach statistical significance on CD19 + and CD3 + cells ( Figure 6B ).

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