Barely Significant
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Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus.

Lupus Sci Med · 2021 · PMC7970264 · PMID 33727237

Europe PMCDOI
1
hedged sentence
0.1600
closest p · 3.2× alpha
0.1600
boldest claim

The sentences

showed a trendp=0.160not close (p > 0.1)
Treatment of B cells with iberdomide resulted in a significant reduction in the percentage of CD27 + IgD - B cells (iberdomide 8.6±13.9 vs vehicle 34.9±19.3, p=0.028), without reducing the percentage of IgD + CD20 low naïve B cells—if anything, treatment with iberdomide showed a trend towards an increase in the percentage of naïve B cells (iberdomide 45.6±19.9 vs vehicle 30.7±18.9, p=0.160) and led to a significant increase in double negative (DN) CD27 - IgD - B cells considered part of the class-switched memory compartment (iberdomide 45.89±16.7 vs vehicle 29.4±16.2, p=0.015) ( figure 2B, C ).

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