SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.

Although the correlation of SPTBN1 with IL-6 (correlation coefficient = -0.258, p-value = 0.147), and SPTBN1 and IL-1β (correlation coefficient = -0.307, p-value = 0.082) did not reach statistical significance in HCV-induced HCC, the trend of inverse relationship is clearly seen in HCV-induced HCC (Figure 1 C-II).

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