For example, ARID1A , which is part of the ATP-dependent chromatin remodeling complex SNF/SWI, was associated with sensitivity to topotecan, a DNA topoisomerase I inhibitor, in STAD ( P BH = 1.68 × 10 −3 ) and nominally significant in UCEC (raw P = 0.016).
For AZD0530 (also known as saracatinib, a Src and Abl inhibitor), we found a previously reported gene set for SRC signaling 22 , which consisted of eight genes, was significantly associated with the drug in CCLE ( P = 3.89 × 10 −4 , NES = 1.91) and marginally significant by the GDSC model ( P = 0.059, NES = 1.48).
BRCA samples treated with paclitaxel showed marginal significance ( P = 0.20, Fig. 4C ), although the group annotated with complete or partial response had significantly higher response than the group with stable or clinical progressive disease ( P = 0.03, Fig. 4D ).