Inflammatory processes linked to major depression and schizophrenic disorders and the effects of polypharmacy in psychiatry: evidence from a longitudinal study of 279 patients under therapy.

We found a close link between treatment regimen and side effects as revealed by a linear regression model in which the mere number of drugs taken simultaneously explained a highly significant ( p < 0.001) proportion of the observed variance in side effects irrespective of the substances involved: 17.8% of the variance of sexuality-related side effects, 11.8% of the variance in gastrointestinal disturbances, 13.3% of the variance in cardiac-respiratory disturbances, and 18.4% of the variance in cardiovascular disturbances.

also in 132,142 other papers

As the monotherapy subgroups were relatively small, the observed differences did not reach statistical significance. 5 Attempts to establish a linear or nonlinear model that predicts response to treatment or non-response from previous history, the acute state of the disorders at baseline, or the chosen treatment regimens failed altogether.

also in 111,027 other papers