The Association of Single-Nucleotide Polymorphism rs13181 in ERCC2 with Risk and Prognosis of Nasopharyngeal Carcinoma in an Endemic Chinese Population.

6 , 7 Indeed, NPC risk in a population in Sichuan, China, showed a trend to be linked to several single nucleotide polymorphisms (SNPs) that lead to amino acid changes such as Lys751Gln (rs13181) in the gene encoding excision repair cross complementation group 2 (ERCC2), which is a key player in the nucleotide excision repair (NER) pathway. 8 Significant associations between NPC susceptibility and rs13181 SNP were also found in a Malaysian population. 9 We are unaware of reports addressing whether this correlation holds in disease-endemic areas of China.

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