Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers.

Patients with ≥ 5 CTCs had a higher relative expression of the epithelial marker KRT19 or the prostate-specific marker KLK3 (p < 0.0001) while EpCAM higher expression was near significance (p = 0.057) (Fig. 2 ) and KLK3 , KRT19 and EpCAM relative expression associated also among them (p < 0.01).

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In this way, low MYCL expression or the lack of hybrid phenotype in V1 associated with early progression, although did not reach statistical significance.

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