Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.

Transl Psychiatry · 2021 · PMC7988147 · PMID 33758173

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

3C ); however, differences did not reach statistical significance ( t = 1.989, df = 13, p = 0.06; t = 1.988, df = 18, p = 0.06) (Fig. 3D ).

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a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

3C ) in the left dHPC revealed a significant hypomethylation in CpG site #1 at −1520 bp ( t = 2.628, df = 18, p = 0.02) and in two CpG sites with a trend toward significance ( t = 2.73, df = 16, p = 0.06; t = 2.09, df = 13, p = 0.06) in PT mice (Fig. 3D ).

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