A decrease of OGT protein level in Oga D285A/+ (OGT: 0.6 ± 0.2 fold change) compared with WT (OGT: 1.0 ± 0.7 fold change) did not reach statistical significance ( t test, p = 0.164).
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Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
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