Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients.

Sci Rep · 2021 · PMC7990915 · PMID 33762647

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did not reach statistical significanceno p-value reported

Regarding PFS, in subgroup analysis with respect to subsequent CDK4/6i+ET or chemotherapy the association between mutated ESR1 (HR = 2.87 [0.80–10.30]; p = 0.105 and HR = 1.88 [0.61–5.79]; p = 0.269, respectively) or mutated TP53 (HR = 1.99 [0.64–6.15]; p = 0.233 and HR = 2.91 [0.87–9.71]; p = 0.082, respectively) and survival did not reach statistical significance.

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