However, this increase in frequency did not reach statistical significance compared with the pembro+AI cohort (p value 0.07, 3.4% mean increase in palbo+pembro+AI cycle 2 compared with −0.05% decrease in pembro+AI cycle 2).
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Pre-existing effector T-cell levels and augmented myeloid cell composition denote response to CDK4/6 inhibitor palbociclib and pembrolizumab in hormone receptor-positive metastatic breast cancer.
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