Barely Significant
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Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway.

Aging (Albany NY) · 2021 · PMC7993665 · PMID 33626512

Europe PMCDOI
1
hedged sentence
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

showed a trendP<0.0001actually significant
After inhibiting TXNIP expression in mice, the HFD + nicotine (low) + si-TXNIP group showed a trend of improved atherosclerotic plaque lesions compared to the HFD + nicotine (low) group (P<0.0001).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.