Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength.

Although firm conclusions were limited by the low number of dogs studied and by the variability in absolute measures from dog to dog ( S1 Table ), the low dose cohort of four dogs showed a trend toward improvement in all but TTJ angle ( Table 1 ).

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Both measures, however, failed to reach significance.

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