Predictive Genetic Variations in the Kynurenine Pathway for Interferon-α-Induced Depression in Patients with Hepatitis C Viral Infection.

J Pers Med · 2021 · PMC7998192 · PMID 33799594

Europe PMC DOI

hedged sentences

0.0280

closest p · 0.6× alpha

0.0280

boldest claim

The sentences

nominally significantp = 0.0280actually significant

Additionally, we obtained two nominally significant SNPs (rs10760581, p = 0.0280; rs941960, p = 0.0280) in KYAT1 (which encodes Kynurenine Aminotransferase 1) in the full-model association tests with recessive modes of inheritance.

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may be significantno p-value reported

Considering that depression may be caused by the additive effects of multiple biopsychosocial factors, if one sex suffers from certain predispositions, the effects of some SNPs may be greater in this sex compared to the other, and there may be significant sex*SNP interactions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.