showed a trendp = 0.1
a trend toward significancep -value < 0.2
A trend toward significance (the boundary of p -value < 0.2) was observed in the OS analysis for metastatic sites (only liver versus other sites, 103 versus 50 months, p = 0.14) while a prior systemic therapy showed a trend in favor also for the DFI (none versus ≥ 1, 14 versus 46 months, p = 0.1).