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Pathogen Dose in Animal Models of Hemorrhagic Fever Virus Infections and the Potential Impact on Studies of the Immune Response.

Pathogens · 2021 · PMC7999429 · PMID 33804381

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a clear trendno p-value reported
As shown, there is a clear trend toward experiments that utilize these high doses, with a number of studies that include some form of analysis of the host immune response to infection.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.