Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA.

Rolipram partially abrogated the AngII-mediated induction of Mmp-2 expression ( Figure 8 A), while a trend for the normalization of the Mmp-9 mRNA levels was detected, although the differences did not reach statistical significance ( Figure 8 B).

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