The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model.

Nutrients · 2021 · PMC8000946 · PMID 33801889

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did not reach statistical significanceno p-value reported

Rats treated with MTX and enteral n-3 PUFA (Group D) as opposed to group C (MTX only) revealed a significant lower intestinal damage score in ileum (32%, p < 0.05) and a trend toward lower injury scores in jejunum; this trend did not reach statistical significance.

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