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Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies' Guidelines.

Pharmaceuticals (Basel) · 2021 · PMC8001498 · PMID 33801304

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an increasing trendno p-value reported
Introduction It is approximated that 250 million people worldwide suffer from osteoarthritis (OA), with an increasing trend in prevalence during the last decades, which continues to rise [ 1 , 2 , 3 ].

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They did, however, note that the observed cartilage quality did not reach statistical significance in the analyzed studies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.