T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome.

The median frequency of circulating activated CD69 + iNKT cells in AGS subjects at baseline (e.g., no reported recent tick bite; no recent mammalian meat ingestion) was 17.2%, which is 2.5 times greater than the median frequency of activated CD69 + iNKT cells in control PBMCs (6.38%), but it did not reach statistical significance ( Table S2 and Figure S4D ).

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