Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.

In the combined datasets, we observed nearly significant correlation (p = 0.066) between high XPO6 mRNA levels and worse relapse-free survival (RFS) in lymph-node-positive, but not lymph-node-negative, patients ( Figure S2E ), and this was confirmed using an individual dataset ( GSE21653 ) ( Finetti et al., 2008 ) ( Figure S2F ).

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