Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis.

PLoS Med · 2021 · PMC8007034 · PMID 33780450

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a strong trendno p-value reported

In addition, exploratory analysis showed that CBD dose also had a significant direct relationship with all-case AEs and a strong trend-level association with treatment-related AEs in RCTs using THC-CBD combination.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.