Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.

PLoS One · 2021 · PMC8009386 · PMID 33784356

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did not reach statistical significanceno p-value reported

All statins showed no differences between each other, but only simvastatin (SMD = 0.92, 95% CI = 0.41 to 1.43) and to a lesser extent lovastatin (SMD = 0.77, 95% CI = 0.22 to 1.32) were significantly better than placebo, with a trend towards improvement for atorvastatin and rosuvastatin that did not reach statistical significance.

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