DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia.

While the vast majority of schizophrenia-associated DMPs remained at least nominally significant (n = 1003, 95.7%; p<0.05) between schizophrenia patients and controls; among those that did not, 25 (2.39%) had a significant effect associated with TRS status.

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We also identified a highly significant increase in a DNA methylation-derived smoking score in patients with schizophrenia, replicating our previous finding ( Hannon et al., 2016a ).

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