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Effect of hypertonic saline in the management of elevated intracranial pressure in children with cerebral edema: A systematic review and meta-analysis.

SAGE Open Med · 2021 · PMC8010820 · PMID 33854775

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showed a trendno p-value reported
However, the CPP showed a trend of early improvement in the HTS group compared to the mannitol group. 29 Roumeliotis et al. examined the impact of hyperosmolar therapies on ICP following administration of first two boluses (ICP > 20 mm Hg) only for 4 h, and the impact of further boluses was not evaluated.

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