Additionally, 12 of these metabolites showed a nominally significant change in post-PEA surgery in the paired sample validation analysis (correcting 15–100% of perturbation versus healthy controls), with seven meeting multiple test corrections including N2,N2-dimethylguanosine and sphingomyelin-(d18:1/22:1, d18:2/22:0, d16:1/24:1) ( supplementary table S5 and figure 4b ).
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Plasma metabolomics exhibit response to therapy in chronic thromboembolic pulmonary hypertension.
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