The histone modification H3K4me3 is altered at the <i>ANK1</i> locus in Alzheimer's disease brain.

Of the six regions assayed, two showed a nominally significant decrease in the level of H3K4me3 in individuals with high compared with low AD neuropathological burden, at the genomic coordinates chr8:41519342-41519460 (primer Set 3: Figure 1 C, fold change [FC] = -0.30, p = 0.033) and chr8:41686181-41686328 (primer Set 5: Figure 1 E, FC = -0.22, p = 0.023), wi

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