Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.

However, we also observed nominally significant ( p < 0.05 uncorrected) positive associations between 5-HI and the left and right frontal poles, left insula, right caudal-middle frontal, right lateral orbitofrontal, and right lingual areas in patients with schizophrenia ( p = 0.03–0.004), whereas the right lateral occipital region had a nominally negative association with 5-HI ( p = 0.05) (Supplementary Table 4 ).

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