DNA Methylation Regulates Transcription Factor-Specific Neurodevelopmental but Not Sexually Dimorphic Gene Expression Dynamics in Zebra Finch Telencephalon.

These analyses demonstrated for example a clearly significant enrichment for ESRRA binding motifs (∼2-fold, P = 4.8E-5) ( Supplementary Data Sheet 1 ), suggesting that the transactivation activity of ESRRA may depend on the DNA methylation status of its binding motif.

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Out of 21 significantly differentially methylated CpGs, 19 show hypermethylation with age, coinciding with a highly significant reduction in expression (4.11-fold reduction, adj.

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