Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study.

Dermatol Ther (Heidelb) · 2021 · PMC8019016 · PMID 33661508

Europe PMC DOI

hedged sentence

0.0739

closest p · 1.5× alpha

0.0739

boldest claim

The sentences

did not reach statistical significancep = 0.0739so close (0.05 < p ≤ 0.1)

Higher IL36G expression was also observed in patients with greater disease severity compared with those with lower disease severity, but this difference did not reach statistical significance at alpha = 0.05 ( p = 0.0739).

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