The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review.

Ther Adv Gastroenterol · 2021 · PMC8020742 · PMID 33868457

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may be significantno p-value reported

16 Despite the large sample size and duration of follow up, there may be significant selection or indication bias.

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may not be significantno p-value reported

83 , 89 – 100 Moreover, established risk factors for CDI such as nosocomial acquisition, age, and recent antibiotic use may not be significant risk factors for CDI in patients with IBD. 94 , 101 – 103 One study of 461 consecutive patients hospitalized for IBD flares, detected toxigenic C. difficile and non-toxigenic C. difficile in 35 (8%) and 10 (2%) hospitalized patients, respectively. 104 In a similarly designed study that instead

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a suggestive trendno p-value reported

pylori was associated with a significantly lower odds of IBD (pOR 0.31, 95% CI 0.21–0.44) and CD (pOR 0.23, 95% CI 0.15–0.35), with a suggestive trend for UC (pOR 0.66, 95% CI 0.34–1.27). 71 Interestingly, there was no significant difference in the odds of IBD overall, CD, or UC between H. pylori exposed, CagA seronegative, and H. pylori non-exposed individuals.

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