All of the 85 lead variants had significant 2df joint test P -values, and none of their 1df interaction P -values approached significance, suggesting these variants influence lipid traits predominantly through main effects.
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Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci.
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Significant interaction effects were also found in three other loci in the genes SLC12A3 (HDL-C), ABCA6 (LDL-C), and MLXIPL (LDL-C), but highly significant main effects are also present.