The Role of Denosumab for Surgical Outcomes in Patients with Giant Cell Tumour of Bone: A Systematic Review.

compared patients receiving no DENO, adjuvant DENO, and both adjuvant and neoadjuvant DENO, and found that mean operating time in minutes was less for patients receiving both neoadjuvant and adjuvant DENO (mean ± standard deviation (SD) = 181.2 ± 38.6 min) when compared with no DENO (199.4 ± 49.5 min) or adjuvant DENO (200.6 ± 69.8 min), but the difference did not reach statistical significance [ 18 ].

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