Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults.

Interestingly, when comparing the latter two models, higher amyloid load showed a nearly significant association with steeper episodic memory slope ( β = −0.12 (SE = −0.068), P = 0.069), but not with lower baseline memory scores ( β = −0.56 (SE = 0.44), P = 0.20).

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