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Spectrum of Germline RET variants identified by targeted sequencing and associated Multiple Endocrine Neoplasia type 2 susceptibility in China.

BMC Cancer · 2021 · PMC8028819 · PMID 33827484

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showed a trendno p-value reported
The mean age at MTC diagnosis of those with compound mutations showed a trend towards younger ages relative to those with single mutations, and there seems to be no need to change the risk grade.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.