Increasing prevalence of resistance to second-line drugs among multidrug-resistant Mycobacterium tuberculosis isolates in Kuwait.

Sci Rep · 2021 · PMC8032671 · PMID 33833390

Europe PMC DOI

hedged sentences

0.1820

closest p · 3.6× alpha

0.1820

boldest claim

The sentences

did not reach statistical significanceP = 0.182not close (p > 0.1)

Although the prevalence of mutations conferring resistance to FQs ( gyrA/gyrB ) and SLIDs ( rrs/eis ) in MDR-TB strains was higher in isolates with an rpoB S450L mutation versus isolates with all other mutations (19 of 73 versus 4 of 29), the difference did not reach statistical significance ( P = 0.182).

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an increasing trendno p-value reported

Although XDR-TB was not detected, an increasing trend in the frequency of pre-XDR-TB was evident in Kuwait as the frequency of mutations conferring resistance to FQs or SLIDs was significantly higher among isolates collected during 2013–2019 versus 2006–2012.

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