In the meta-analysis, a subgroup of mainly still unpublished, smaller, well-conducted placebo-controlled trials showed a trend towards a benefit for HCQ-treated patients with lower mortality (OR 0.88, 95% CI 0.55–1.41) ( Axfors et al., 2021 ).
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A call to caution when hydroxychloroquine is given to elderly patients with COVID-19.
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