Progressive Sarcopenia Correlates with Poor Response and Outcome to Immune Checkpoint Inhibitor Therapy.

Interestingly, we observed a strong trend towards a lower MMA ( p = 0.073), suggesting a higher amount of muscular fat deposition in patients with more advanced tumor stage ( Supplementary Materials Figure S2B ) as well as a significant stepwise reduction of the MMA in patients with an increasingly impaired ECOG PS ( Supplementary Materials Figure S2C ).

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Here, we observed only a slight trend towards a better outcome in patients with L3SMI/MMA values above the cohort’s median (76.79 mm 2 /cm and 34.55 HU, Figure 3 A and B).

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