Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer.

Cancers (Basel) · 2021 · PMC8036662 · PMID 33804961

Europe PMC DOI

hedged sentence

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closest p · 1.2× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

We observed a higher proportion of men with aggressive prostate cancer carrying pathogenic variants in ATM than that in men with non-aggressive prostate cancer (14/787 carriers, 0.02% and 5/769 carriers, 0.01%, respectively), although the difference did not reach statistical significance ( p = 0.06) [ 17 ].

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