Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression.

The observed changes in neuroblastoma cells did not reach statistical significance which could be attributed to two factors: (1) cell type-specific effects—different levels of available mRNAs capable of regulation by miR-483-5p between HEK293 and SK-N-MC, with more targets present in neuroblastoma cells; (2) technical issues—difference in the transfection efficiency; lower efficiency is usually achieved in neuroblastoma cells.

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