Could Primary Chemoradiotherapy in T2 Glottic Cancers Yield Results Comparable to Primary Radiotherapy in T1? Considerations from 531 German Early Stage Patients.

Consistently, all recent meta-analyses report LC rates without significant difference between TLM and pRT but highly significant differences in LP ( Table 4 ).

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From recent meta-analyses, however, there is growing evidence, that although pRT and TLM are equivalent in terms of local control (LC), there may be significant differences in overall survival (OS) and laryngeal preservation (LP) [ 18 , 19 , 20 , 21 ].

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The differences in outcome did not reach statistical significance because of low numbers of patients in each arm (between 25 and 57 patients).

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