At all tested BMP4/6 concentrations, Ext1 gt/gt chondrocytes showed a trend towards a stronger BMP-response compared to WT cells, which reached significance under stimulation with 10 ng/mL BMP ( Figure 2 C).
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Heparan Sulfate Deficiency in Cartilage: Enhanced BMP-Sensitivity, Proteoglycan Production and an Anti-Apoptotic Expression Signature after Loading.
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