While these differences in decreasing migration were statistically significant between the 48-hour hypoxic NK92-Exo and NK92-Exo groups (P<0.05, P<0.01; Figure 4B,D ), they did not reach statistical significance between the 24-hour hypoxic NK92-Exo and NK92-Exo groups in the MCF-7 cells (P=0.98) or the A2780 cells (P=0.26) ( Figure 4B,D ).
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Hypoxia enhances the production and antitumor effect of exosomes derived from natural killer cells.
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