However, this observation of decreasing HFO rates with age failed to reach statistical significance, 20 in line with the lack of age-dependent changes in scalp HFO rates in a longitudinal paediatric tuberous sclerosis study. 9 The observation of age-independent scalp HFO rates is surprising in light of the gradually increasing power in other higher frequency bands with age, as recently confirmed in a study of cortical rhythm maturation through childhood, 21 thus adding to the controversy surrounding age-related changes in scalp HFO rates.
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